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迪克（托马斯·杰恩 Thomas Jane 饰）和吉娜（劳伦·泽曼 Lauren German 饰）是一对新婚夫妇，他们驾车沿着州际公路前往塞多纳，尽情享受这趟蜜月之旅。夜幕降临，迪克不知不觉间偏离了原来的95号公路，所谓春宵一刻值千金，这对夫妇似乎并不太在意迷路这件事，反而尽享欲望和速度所带来的双重快感。当激情过后，却有一个全身是血的男人（康·谢尔 Con Schell 饰）突然出现在他们的车前。迪克救助了受伤的男子，而对方则试图杀掉他。纠缠厮打之中，受伤男子被迪克所杀。为了防止惹上麻烦，夫妇俩将尸体偷偷掩埋。 原本以为一切不快就此结束，谁曾想迪克和吉娜的诡异旅程才刚刚开始……。American psychologist John Holden arrives in London to participate in a symposium aiming to expose witchcraft and devil-worship as a fraud, with attention centered on a cult run by a Julian Karswell. Debarking his plane, Holden learns that the symposium leader, Henry Harrington, has suddenly died and he is now in charge. What only the audience knows is that Harrington was clearly killed by a demon, apparently summoned by Karswell to avenge his persecution. Despite both threatening and cajoling behavior by Karswell, Holden determines to proceed, though the only cult member willing to talk about his experiences is in a prison psychiatric ward, catatonic after allegedly killing yet another cult member. However, Harrington's niece, Joanna, believes, based on her uncle's notes, that Karswell may indeed have some satanic powers derived from an ancient tome in an obscure language which he has been able to translate, and attempts to warn the skeptic Holden. Karswell's mother also attempts to warn Holden off. However, the thing which begins to most get to Holden are the occasional, but mounting, sensory and mental disturbances he begins experiencing after an encounter with Karswell, and the discovery that, during this encounter, Karswell secretly slipped a slip of parchment with a curse in runic symbols on it into Holden's belongings, a parchment identical to one Harrington recorded having had passed to him in a similar manner shortly before his death... [N.B. Holden at no point stays at the Karswell estate].。